The endocrine diseases and disorders that affect the pediatric age group are varied and numerous, and their consequences are particularly serious, as they could have a lasting influence as the child grows into adulthood. For more than a decade, this book has provided a practical and simple approach to the diagnosis and management of common endocrine problems in clinical practice in India. It has served as an invaluable guide on the subject to practicing pediatricians, postgraduate students and other health professionals.
With contributions from experts on the subject from all over the world, this comprehensively updated edition aims to present current knowledge about diagnostic techniques and treatment in a simple yet erudite manner. Incorporating suggestions received over the years, new colour photos and recent research data, this edition will be helpful to all medical professionals involved in caring for children.
Meena P. Desai MD DCH, Hon. Consultant, Endocrinology Division, B.J. Wadia Hospital for Children and Institute of Child Health and Research Centre, Mumbai; Hon. Pediatrician, Sir H.N. Hospital and Research Centre; Formerly, Hon. Director, Sir H.N. Medical Research Society, Mumbai
P. S. N. Menon MD MNAMS, Consultant and Head, Department of Pediatrics, Jaber Al-Ahmed Armed Forces Hospital, Kuwait; Formerly, Professor of Pediatrics, All India Institute of Medical Sciences, New Delhi
Vijayalakshmi Bhatia MD, Professor, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
Contributors
Preface to Third Edition
Preface to Second Edition
Preface to First Edition
Colour Plates
1: Fundamentals of Pediatric Endocrinology
P. S. N. Menon, Vijayalakshmi Bhatia, Meena P. Desai
2: Molecular Basis of Pediatric Endocrinopathies
Kanakadurga Singer, Prapai Dejkhamron, Ram K. Menon
3: Fetal and Neonatal Endocrinology
Meena P. Desai
3.1 Fetal and Neonatal Endocrine System
3.2 Metabolic and Endocrine Consequences of Intrauterine Growth Retardation
Paul Hofman, Wayne Cutfield
4: Normal and Abnormal Growth
Vijayalakshmi Bhatia
4.1 Normal Growth
Vijayalakshmi Bhatia, Preeti Dabadghao
4.2 Growth Retardation
Preeti Dabadghao, Vijayalakshmi Bhatia
4.3 Tall Stature and Overgrowth Syndromes
4.4 Skeletal Dysplasias
Madhulika Kabra
5: Disorders of Growth Hormone Production and Action
5.1 Growth Hormone Deficiency and Insensitivity
Meena P. Desai, Prisca Colaco
5.2 CNS Tumours and Hypopituitarism
Vaman Khadilkar
5.3 Growth Hormone Therapy: Principles and Practice
Christopher T. Cowell, Ben J. Wheeler, Helena K. Gleeson
6: Disorders of Pubertal Development
P. S. N. Menon
6.1 Physiology of Puberty
Anju Seth, Rajni Sharma
6.2 Delayed Puberty
Margaret Zacharin, Indraneel Banerjee
6.3 Precocious Puberty
Anurag Bajpai, P. S. N. Menon
6.4 Gynecomastia
Sivaprakash Somasundaram, A. C. Ammini
6.5 Peripubertal Hyperandrogenism and Hirsutism
Gunjan Garg, A.C. Ammini
6.6 Gynecological Problems in Childhood and Adolescence
Margaret Zacharin, Sonia R. Grover
7: Turner Syndrome
Nalini S. Shah, Mathew John
8: Disorders of the Thyroid Gland
8.1 The Thyroid Gland
8.2 Hypothyroidism, Goitre and Thyroid Neoplasia
8.3 Hyperthyroidism
Padma S. Menon
8.4 Health Consequences of Iodine Deficiency in Children
Anju Seth
9: The Adrenal Glands
9.1 The Adrenal Cortex—Physiology
9.2 Disorders of Adrenocortical Biosynthesis
Palany Raghupathy
9.3 Hyperfunction of the Adrenal Cortex
Nalini S. Shah, Anurag Ranjan Lila
9.4 Adrenal Insufficiency
Prisca Colaco
9.5 Glucocorticoid Therapy
9.6 Endocrine Hypertension in Children
10: Disorders of Sex Development
10.1 Evaluation of a Child with Ambiguous Genitalia—Diagnosis and Management
Garry L. Warne, Nella A. Greggio
10.2 Micropenis
M. Vijayakumar, P. S. N. Menon
10.3 Undescended Testes
Anna Simon, P. S. N. Menon
11: Disorders of Water, Electrolyte and Acid–Base Homeostasis
11.1 Disorders of Water and Electrolyte Homeostasis
11.2 Renal Tubular Acidosis
Sudha Rao Chandrashekhar
12: Diabetes Mellitus
12.1 Type 1 Diabetes Mellitus—Pathogenesis and Prevention
Eesh Bhatia
12.2 Type 2 Diabetes Mellitus and Other Forms of Diabetes in Children
Mathew John, Nalini S. Shah
12.3 Ambulatory Management of Diabetes Mellitus
Anju Virmani
12.4 Acute and Chronic Complications of Diabetes in Childhood
Aspi Irani
12.5 The Infant of a Diabetic Mother
13: Hypoglycemia in Infancy and Childhood
Sudha Rao Chandrashekhar, Meena P. Desai
14: Childhood Obesity
Usha Sriram
15: Disorders of Calcium, Phosphorus and Bone Metabolism
15.1 Normal Mineral Metabolism
Raja Padidela, Ambrish Mithal, Zulf Mughal
15.2 Evaluation of Children with Bone and Mineral Disorders
15.3 Hypocalcemia, Hypercalcemia and Disorders of the Parathyroid Glands
Zulf Mughal, Raja Padidela
15.4 Metabolic Bone Disease
Zulf Mughal
16: Polyglandular Endocrine Syndromes
Rajiv Singla, Nikhil Tandon
17: Endocrine Consequences of Systemic Disorders
17.1 Growth and Endocrine Function in β-Thalassemia Major
Louis C. K. Low
17.2 Growth and Endocrine Dysfunction in Survivors of Childhood Cancer
Meena P. Desai, Purna Kurkure
18: Principles of Hormone Measurement